Research highlights

Our pick of the latest HPV related research updates.

The search for biomarkers of transforming HPV infection continues. The following papers provide interesting state-of-the-art assessments for some of the more promising candidates:

  • Potential role of microRNAs in the treatment and diagnosis of cervical cancer. Shen S, Zhang S, Liu P, Wang J, Du H.Cancer Genet. 2020 Sep 22;248-249:25-30. doi: 10.1016/j.cancergen.2020.09.003. Online ahead of print.PMID: 32987255 Review.
  • The early detection of cervical cancer. The current and changing landscape of cervical disease detection.  Shiraz A, Crawford R, Egawa N, Griffin H, Doorbar J.Cytopathology. 2020 Jul;31(4):258-270. doi: 10.1111/cyt.12835.PMID: 32301535 Review.
  • The use of host cell DNA methylation analysis in the detection and management of women with advanced cervical intraepithelial neoplasia: a review.  Kremer WW, Steenbergen R, Heideman D, Kenter GG, Meijer C.BJOG. 2020 Jul 3. doi: 10.1111/1471-0528.16395. Online ahead of prin

Self-sampling is being used increasingly to engage women, particularly hard to reach women in cervical screening.  The following papers provide a perspective on key issues and developments

  • Self-Collection for Cervical Screening Programs: From Research to Reality. Hawkes D, Keung MHT, Huang Y, McDermott TL, Romano J, Saville M, Brotherton JML.Cancers (Basel). 2020 Apr 24;12(4):1053. doi: 10.3390/cancers12041053
  • Analytical performance of HPV assays on vaginal self-collected vs practitioner-collected cervical samples: the SCoPE study.  Saville M, Hawkes D, Keung M, Ip E, Silvers J, Sultana F, Malloy MJ, Velentzis LS, Canfel L K, Wrede CD, Brotherton J.J Clin Virol. 2020 Jun;127:104375. doi: 10.1016/j.jcv.2020.104375.
  • Methylation markers FAM19A4 and miR124-2 as triage strategy for primary HPV screen positive women; A large European multi-center study.Bonde J, Floore A, Ejegod D, Vink FJ, Hesselink A, van de Ven PM, Oštrbenk Valenčak A, Pedersen H, Doorn S, Quint WG, Petry KU, Poljak M, Stanczuk G, Cuschieri K, de Sanjosé S, Bleeker M, Berkhof J, Meijer CJLM, Heideman DAM, Alcaniz E, Rothe B, Hortal MT, Del Pino M, Bhatia R.