Recent key publications from the SHINe community

Bonde J, Floore A, Ejegod D, Vink FJ, Hesselink A, van de Ven PM, Oštrbenk Valenčak A, Pedersen H, Doorn S, Quint WG, Petry KU, Poljak M, Stanczuk G, Cuschieri K, de Sanjosé S, Bleeker M, Berkhof J, Meijer CJLM, Heideman DAM, Alcaniz E, Rothe B, Hortal MT, Del Pino M, Bhatia R. Methylation markers FAM19A4 and miR124‐2 as triage strategy for primary HPV screen positive women; A large European multi-center study.

Stevenson A, Wakeham K, Pan J, Kavanagh K, Millan D, Bell S, McLellan D, Graham SV, Cuschieri K.J. Droplet digital PCR quantification suggests that higher viral load correlates with improved survival in HPV-positive oropharyngeal tumours Clin Virol. 2020 Aug;129:104505. doi: 10.1016/j.jcv.2020.104505. Epub 2020 Jun 20.PMID:32604039

Cameron RL, Cuschieri K, Pollock KGJ. Baseline HPV prevalence in rectal swabs from men attending a sexual health clinic in Scotland: assessing the potential impact of a selective HPV vaccination programme for men who have sex with men. Sex Transm Infect. 2020;96(1):55‐57. doi:10.1136/sextrans-2018-053668

Craig SG, Anderson LA, Moran M, Graham L, Currie K, Rooney K, Robinson M, Bingham V, Cuschieri KS, McQuaid S, Schache AG, Jones TM, McCance D, Salto-Tellez M, McDade SS, James JA. Comparison of Molecular Assays for HPV Testing in Oropharyngeal Squamous Cell Carcinomas: A Population-Based Study in Northern Ireland. Cancer Epidemiol Biomarkers Prev. 2020;29(1):31‐38. doi:10.1158/1055-9965.EPI-19-0538

Guerendiain D, Healy K, Johannessen I, Cuschieri K. Implication of human papillomavirus (HPV) infection in the paediatric population [published online ahead of print, 2019 Sep 4]. BMJ Sex Reprod Health. 2019;bmjsrh-2018-200175. doi:10.1136/bmjsrh-2018-200175

Vink FJ, Meijer CJLM, Clifford GM, Poljak M, Oštrbenk A, Petry KU, Rothe B, Bonde J, Pedersen H, de Sanjosé S, Torres M, Del Pino M, Quint WGV, Cuschieri K, Boada EA, van Trommel NE, Lissenberg-Witte BI, Floore AN, Hesselink AT, Steenbergen RDM, Bleeker MCG, Heideman DAM. FAM19A4/miR124-2 methylation in invasive cervical cancer: A retrospective cross-sectional worldwide study [published online ahead of print, 2019 Aug 7]. Int J Cancer. 2019;10.1002/ijc.32614. doi:10.1002/ijc.32614

Aldhous MC, Bhatia R, Pollock R, Vragkos D, Cuschieri K, Cubie HA, Norman JE, Stock SJ. HPV infection and pre-term birth: a data-linkage study using Scottish Health Data. Wellcome Open Res. 2019;4:48. Published 2019 Mar 8. doi:10.12688/wellcomeopenres.15140.1

Traynor D, Duraipandian S, Bhatia R, Cuschieri K, Martin CM, O'Leary JJ, Lyng FM. The potential of biobanked liquid based cytology samples for cervical cancer screening using Raman spectroscopy. J Biophotonics. 2019;12(7):e201800377. doi:10.1002/jbio.201800377

Cuschieri K, Lorincz AT, Nedjai B. Human Papillomavirus Research: Where Should We Place Our Bets?. Acta Cytol. 2019;63(2):85‐96. doi:10.1159/000493800

Palmer T, Wallace L, Pollock KG, Cuschieri K, Robertson C, Kavanagh K, Cruickshank M. Prevalence of cervical disease at age 20 after immunisation with bivalent HPV vaccine at age 12-13 in Scotland: retrospective population study. BMJ. 2019;365:l1161. Published 2019 Apr 3. doi:10.1136/bmj.l1161

Pan J, Kavanagh K, Cuschieri K, Pollock KG, Gilbert DC, Millan D, Bell S, Graham SV, Williams ARW, Cruickshank ME, Palmer T, Wakeham K. Increased risk of HPV-associated genital cancers in men and women as a consequence of pre-invasive disease. Int J Cancer. 2019;145(2):427‐434. doi:10.1002/ijc.32126

Cuschieri K, Schuurman R, Coughlan S. Ensuring quality in cervical screening programmes based on molecular human papillomavirus testing. Cytopathology. 2019;30(3):273‐280. doi:10.1111/cyt.12679

Bhatia, R, Kavanagh, K, Stewart, J, Moncur, S, Serrano, I, Cong, D, Cubie, H, Haas, J, Busby-Earle, C, Williams, A, Howie, S & Cuschieri, K 2018, 'Host chemokine signature as a biomarker for the detection of pre-cancerous cervical lesions' Oncotarget, vol 9, pp. 18548-18558. DOI: 10.18632/oncotarget.24946

Cuschieri K, Ronco G, Lorincz A, Smith L, Ogilvie G, Mirabello L, Carozzi F, Cubie H, Wentzensen N, Snijders P, Arbyn M, Monsonego J, Franceschi S. Eurogin roadmap 2017: Triage strategies for the management of HPV-positive women in cervical screening programs. Int J Cancer. 2018;143(4):735‐745. doi:10.1002/ijc.31261

Stevenson A, Kavanagh K, Pan J, Stevenson L, Griffin H, Doorbar J, Scott E, Deeny M, Cuschieri K, Graham SV. Risk stratification of cervical disease using detection of human papillomavirus (HPV) E4 protein and cellular MCM protein in clinical liquid based cytology samples. J Clin Virol. 2018;108:19‐25. doi:10.1016/j.jcv.2018.08.011

Klymenko T, Gu Q, Herbert I, Stevenson A, Iliev V, Watkins G, Pollock C, Bhatia R, Cuschieri K, Herzyk P, Gatherer D, Graham SV (2017) RNASeq analysis of differentiated keratinocytes reveals a massive response to late events during human papillomavirus type 16 infection, including loss of epithelial barrier function. J Virol JVI.01001-17, doi:10.1128/JVI.01001-17.

Kavanagh K, Pollock KG, Cuschieri K, Palmer T, Cameron RL, Watt C, Bhatia R, Moore C, Cubie H, Cruickshank M, Robertson C (2017) Changes in the prevalence of human papillomavirus following a national bivalent human papillomavirus vaccination programme in Scotland: a 7-year cross-sectional study. Lancet Infect Dis Sep 28. pii: S1473-3099(17)30468-1: doi:10.1016/S1473-3099(17)30468-1.

Cruickshank, M.E., Pan, J., Cotton, S.C., Kavanagh, K., Robertson, C., Cuschieri, K., Cubie, H., Palmer, T., and Pollock, K.G. (2017). Reduction in colposcopy workload and associated clinical activity following human papillomavirus (HPV) catch-up vaccination programme in Scotland: an ecological study. BJOG Int. J. Obstet. Gynaecol.

Munro, A., Gillespie, C., Cotton, S., Busby-Earle, C., Kavanagh, K., Cuschieri, K., Cubie, H., Robertson, C., Smart, L., Pollock, K., et al. (2017). The impact of human papillomavirus type on colposcopy performance in women offered HPV immunisation in a catch-up vaccine programme: a two-centre observational study. BJOG Int. J. Obstet. Gynaecol.

Pattle, S.B., Utjesanovic, N., Togo, A., Wells, L., Conn, B., Monaghan, H., Junor, E., Johannessen, I., Cuschieri, K., and Talbot, S. (2017). Copy number gain of 11q13.3 genes associates with pathological stage in hypopharyngeal squamous cell carcinoma. Genes. Chromosomes Cancer 56, 185–198.

Wakeham, K., Kavanagh, K., Cuschieri, K., Millan, D., Pollock, K.G., Bell, S., Burton, K., Reed, N.S., and Graham, S.V. (2017). HPV status and favourable outcome in vulvar squamous cancer. Int. J. Cancer 140, 1134–1146.

Conway, D.I., Robertson, C., Gray, H., Young, L., McDaid, L.M., Winter, A.J., Campbell, C., Pan, J., Kavanagh, K., Kean, S., Bhatia R, Cubie H, Clarkson JE, Bagg J, Pollock KG, Cuschieri K.. (2016). Human Papilloma Virus (HPV) Oral Prevalence in Scotland (HOPSCOTCH): A Feasibility Study in Dental Settings. PloS One 11, e0165847.

Cuschieri, K., Kavanagh, K., Moore, C., Bhatia, R., Love, J., and Pollock, K.G. (2016b). Impact of partial bivalent HPV vaccination on vaccine-type infection: a population-based analysis. Br. J. Cancer 114, 1261–1264.

Moore, C., Duvall, E., Braby, E., Reid, G., Docherty, E., Grieve, L., Cubie, H., Graham, C., and Cuschieri, K. (2016). Clinical sensitivity of HPV assays for the detection of high grade cervical disease in cervical samples treated with glacial acetic acid. J. Clin. Virol. Off. Publ. Pan Am. Soc. Clin. Virol. 79, 32–35.

Stanczuk, G., Baxter, G., Currie, H., Lawrence, J., Cuschieri, K., Wilson, A., and Arbyn, M. (2016). Clinical validation of hrHPV testing on vaginal and urine self-samples in primary cervical screening (cross-sectional results from the Papillomavirus Dumfries and Galloway-PaVDaG study). BMJ Open 6, e010660.

Bhatia R, Kavanagh K, Cubie HA, Serrano I, Wennington H, Hopkins M, et al. Use of HPV testing for cervical screening in vaccinated women-Insights from the SHEVa (Scottish HPV Prevalence in Vaccinated Women) study. Int J Cancer. 2016 Jun 15;138(12):2922–31.

Stanczuk G, Baxter G, Currie H, Lawrence J, Cuschieri K, Wilson A, Arbyn M. Clinical validation of hrHPV testing on vaginal and urine self-samples in primary cervical screening (cross-sectional results from the Papillomavirus Dumfries and  Galloway-PaVDaG study). BMJ Open. 2016 April;6(4):e010660.

Palmer TJ, McFadden M, Pollock KGJ, Kavanagh K, Cuschieri K, Cruickshank M, et al. HPV immunisation and increased uptake of cervical screening in Scottish women; observational study of routinely collected national data. Br J Cancer. 2016 Mar 1;114(5):576–81.

Cuschieri K, Bhatia R, Cruickshank M, Hillemanns P, Arbyn M. HPV testing in the context of post-treatment follow up (test of cure). J Clin Virol Off Publ Pan Am Soc Clin Virol. 2016 Mar;76 Suppl 1:S56–61.

Giakoumelou S, Wheelhouse N, Cuschieri K, Entrican G, Howie SEM, Horne AW. The role of infection in miscarriage. Hum Reprod Update. 2016 Feb;22(1):116–33.

Cameron RL, Kavanagh K, Pan J, Love J, Cuschieri K, Robertson C, Ahmed S, Palmer T, Pollock K.C.J. Human Papillomavirus Prevalence and Herd Immunity after Introduction of Vaccination Program, Scotland, 2009-2013. Emerg Infect Dis. 2016 Jan;22(1):56–64.

Müller M, Wasson CW, Bhatia R, Boxall S, Millan D, Goh GYS, et al. YIP1 family member 4 (YIPF4) is a novel cellular binding partner of the papillomavirus E5 proteins. Sci Rep. 2015 Aug 3;5:12523

Hanley SJB, Pollock KGJ, Cuschieri K. Peripheral Sympathetic Nerve Dysfunction in Adolescent Japanese Girls Following Immunization with the Human Papillomavirus Vaccine. Intern Med Tokyo Jpn. Epub 2015 Aug 1;54(15):1953.

Mesher D, Cuschieri K, Hibbitts S, Jamison J, Sargent A, Pollock KG, Powell N, Wilson R, McCall F, Fiander A, Soldan K. Type-specific HPV prevalence in invasive cervical cancer in the UK prior to national HPV immunisation programme: baseline  for monitoring the effects of immunisation. J Clin Pathol. 2015 Feb;68(2):135-40. doi: 10.1136/jclinpath-2014-202681. 2015 Feb. PubMed PMID: 25410654.

Cubie HA, Canham M, Moore C, Pedraza J, Graham C, Cuschieri K  Evaluation of commercial HPV assays in the context of post-treatment follow-up: Scottish Test of Cure Study (STOCS-H).  JClin Path Online First, published on January 16, 2014; doi:10.1136/jclinpath-2013-202014

Kavanagh K, Pollock KG, Potts A, Love J, Cuschieri K, Cubie H, Robertson C, Donaghy M. Introduction and sustained high coverage of the HPV bivalent vaccine leads to a reduction in prevalence of HPV 16/18 and closely related HPV types. Br J Cancer. 2014 May 27;110(11):2804-11. doi: 10.1038/bjc.2014.198. Epub 2014 Apr 15. PubMed PMID: 24736582; PubMed Central PMCID: PMC4037824.

Canham M, Charsou C, Stewart J, Moncur S, Hoodless L, Bhatia R, Cong D, Cubie H, Busby-Earle C, Williams A, McLoughlin V, Campbell JD, Cuschieri K, Howie S. Increased cycling cell numbers and stem cell associated proteins as potential biomarkers for high grade human papillomavirus+ve pre-neoplastic cervical disease. PLoS One. 2014 Dec 22;9(12):e115379. doi: 10.1371/journal.pone.0115379.  eCollection 2014. PubMed PMID: 25531390; PubMed Central PMCID: PMC4274002.

Cuschieri K, Brewster DH, Graham C, Nicoll S, Williams AR, Murray GI, Millan D, Johannessen I, Hardie A, Cubie HA. Influence of HPV type on prognosis in patients diagnosed with invasive cervical cancer. Int J Cancer. 2014 Dec 1;135(11):2721-6. doi: 10.1002/ijc.28902. Epub 2014 Apr 29. PubMed PMID: 24740764.

Pollock KG, Kavanagh K, Potts A, Love J, Cuschieri K, Cubie H, Robertson C, Cruickshank M, Palmer TJ, Nicoll S, Donaghy M. Reduction of low- and high-grade cervical abnormalities associated with high uptake of the HPV bivalent vaccine in Scotland. Br J Cancer. 2014 Oct 28;111(9):1824-30. doi: 10.1038/bjc.2014.479. Epub 2014 Sep 2. PubMed PMID: 25180766.

Chambers G, Klymenko T, Siquiera R, Gatherer D, Millan D, Cuschieri K, Cubie HA, Graham SV. Human papillomavirus mRNA detection in liquid base cytology samples – novel insights into viral gene regulation and biomarker development. J Med Virol 2013;  [Epub ahead of print 2013 Oct 19; doi: 10.1002/jmv.23793]; PubMed PMID: 24142394.

Kavanagh K, Sinka K, Cuschieri K, Love J, Potts  A, Pollock KGJ, Robertson C, Cubie H, Donaghy M. Estimation of HPV prevalence in the general Scottish population; monitoring of future vaccine impact. BMC Infectious Diseases 2013; 13: 259. PubMed PMID:24188790

Cruickshank ME, Cubie HA.  Cervical screening: primary human papillomavirus testing. Editorial, BJOG February 2012; 119: 650-652.